Pharmaceutical Granulation and Compression

GRANULATION AND COMPRESSION Experts

Michael H. Rubinstein B.Pharm., Ph.D., M.R.Pharm.S., M.I.Chem.E., C.Eng., Q.P. (Course Director) Professor Rubinstein is Chairman and Co-Founder of Quay Pharmaceuticals Ltd., a contract pharmaceutical R & D and Clinical Trials Manufacturing company in North Wales. Previously he was Professor of Pharmaceutical Technology and Director of the School of Pharmacy and Chemistry at Liverpool John Moores University. His research interests include the examination of the granulation process and he has published and lectured widely in the field of tableting technology and the formulation of solid dosage forms. Professor Rubinstein has worked for AstraZeneca and GlaxoSmithKline in production technical support, pharmaceutical development and research. He has published over 200 research papers and articles in the area of solid dosage form technology and in particular in tablet compression. He lead one of the only academic research teams using a high speed Compaction Simulator to fundamentally characterise powder compression. Professor Rubinstein is both a Chemical Engineer and a Pharmacist with Q.P. Status, is the author of 5 books in pharmaceutical technology and two patents and is the series editor of the book series in Pharmaceutical Technology now published by Taylor & Francis Ltd. Professor Rubinstein is a consultant to a number of pharmaceutical companies and governments and is the Conference Co-Ordinator for the annual Pharmaceutical Technology Conferences.

Geert Verreck M.Eng., Ph.D.

Dr Verreck is a Scientist in the Pharmaceutical Sciences Department of Johnson and Johnson in Belgium. He is responsible for the evaluation of the solid dispersion approach for new active compounds, including hot melt extrusion and solubility techniques. He has published 37 papers and is the author of 6 patents in this area.

Ian Smales B.Sc.

Mr Smales is an Associate Scientist at Pfizer Central Research and has responsibilities for optimization, scale-up and technology transfer of pharmaceutical products. He has specialist expertise in wet and dry granulation and in particular roller compaction.

Paul Burton C.Chem, M.R.S.C.

Mr Burton has had extensive experience as a Formulation and Process Development Scientist with Beecham Products, Cyanamid UK and SmithKline Beecham Pharmaceuticals. He has been involved in new product introduction, scale-up of solid dosage forms and process validation. Currently he is Process Technology Manager for Glatt Protech where he has responsibility for applications of fluidised bed technology, high shear granulation and tablet coating technologies.

Terry Lewis

Mr Lewis is an independent Consultant and was formerly Operations Manager at I.Holland Ltd., UK. His is accountable for all technical activities of the company and has 28 years expertise in compression and tooling problems.

Marina Levina MSc., Ph.D.

Dr Levina is a Lead Product Owner, OSD at GlaxoSmithKline responsible for Global Supply Oncology products. Previously, she worked as a Global Technical Manager, Excipients and Modified Release at Colorcon Ltd. Dr Levina has experience in the production of tablets by conventional and by ultrasound assisted compaction and with the development of various solid oral dose formulations for both immediate release and modified release applications. She has published over 70 research papers and communications in the area of Pharmaceutical Technology, including book chapters, peer-reviewed articles and poster abstracts presented at more than 20 national and international conferences and seminars. She is an Editorial Advisory Board member and reviewer for international pharmaceutical journals.