- GMP and Compliance
- Pharmaceutical Product Development
- Development and Manufacture of Effervescent Tablets
- HPLC Analytical Method Development and Validation
- Hands-on Tablet Development including the principles of pre-formulation, formulation and process dev
- Introduction to LC-MS for Pharma Industry
- Introduction to Photostability
- Introduction to Sterile Product Manufacture for New Starters and Junior Staff
- Introduction to Sterile Product Manufacture for those with a cGMP basic understanding
- Pharmaceutical Packaging - an introductory course
- Pharmacokinetics in Drug Development - an integrated approach
- Preformulation Studies for Tablet Development
- QbD and Lifecycle Management for Analytical Methods
- Quantitative Bioanalysis using LC-MS for Pharma Industry
- Stability Testing in Biological Product Development and Manufacturing
- Stability Testing in Pharmaceutical Development and Manufacture
- Tablet Formulation Development
- Tablet Formulation Development - Formulation development in practice
- Tablet Process Development, Validation and the Application of QbD
- Technology Transfer
- Pharmaceutical Manufacturing Support
- Pharmaceutical R&D Support
- In-house Training Courses
Introduction to LC-MS for Pharma Industry
No Course Dates Currently Available
Description
This one-day course provides an introduction to technology and (potential) application areas of combined liquid chromatography-mass spectrometry (LC-MS) in small-molecule pharmaceutical industry. The morning sessions provide a clear technology overview, introducing analyte ionization techniques, different types of mass analysers, and important data acquisition strategies. The two afternoon sessions focus on applications in quantitative and qualitative analysis, respectively.
Course Programme
The course will commence with registration and coffee at 8.30, course proper starts at 9.00 and will finish at 17.00
09:00 Introduction.
- Identifying the pharmaceutical application areas for LC-MS.
- Principles of LC-MS and LC-MS-MS.
- Data acquisition strategies in LC-MS.
10:30 Coffee break
10:45 Solutions by LC-MS:
- Instrumentation overview.
- Electrospray and APCI.
- Flow-rate and mobile-phase composition.
- Different types of mass analysers: how and when about single quadrupole, triple quadrupole, ion-trap, and time-of-flight instruments.
12:30 Lunch
13:30
- Potential and limitations of LC-MS in quantitative (bio)analysis.
- General workflow in quantitative analysis.
- Selected reaction monitoring.
- Analytical strategies involved in bioavailability, PK/PD studies, metabolic stability, genotoxic impurities.
- Validation issues.
15:15 Coffee break
15:30
- LC-MS in qualitative applications.
- Fragmentation in MS-MS as a tool for structure elucidation, Multistage MSn and accurate-mass determination.
- Software tools.
- Applications in checking compound identity, impurity profiling, and metabolite identification.
17:00 End of the course
